Innovative therapies against tumors

RNA molecule: Regulatory RNAs can be used as targets to combat the onset of cancers (Image: Vossman, Wikipedia).
RNA molecule: Regulatory RNAs can be used as targets to combat the onset of cancers (Image: Vossman, Wikipedia).

Institutional Communication Service

7 June 2017

A team of researchers at the Institute of Oncology Research (IOR, affiliated with USI Faculty of Biomedical Sciences) has identified a new class of regulatory RNAs, which are able to act as molecular switches and can contribute in controlling the genetic evolution processes that are responsible for some cancer pathologies. 

The study, led by IOR Director Prof. Carlo Catapano and published on the scientific journal Nature Communications, has put together different data from various experimental models and clinical specimens, showing that a specific regulatory RNA could contribute to epigenetic silencing (change in heritability) of an important gene able to protect the prostate cells from potentially cancerous mutations. 

The RNA is a polymeric molecule essential in various biological roles in coding, decoding, regulation of genes. Together with the DNA it constitutes one of the major macromolecules essential for all known forms of life. According to researchers, the use of RNAs as targets could limit the onset of cancer.

The research operates in an emerging and interesting study area for both understanding tumor transformation processes, and for the development of possible clinical applications for diagnostic, prognostic and therapeutic purposes. According to Prof. Carlo Catapano: “The study has shown for the first time the interconnection between genetic alterations, structure and function of regulatory RNAs and epigenetic processes. This means that in a near future, thanks to medications acting on these “targets”, we will be able to intervene on the underlying genetic conditions, therefore preventing or slowing down cancer development”.

The article: http://www.nature.com/articles/ncomms15622
Pisignano, G. et al. A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers. Nat. Commun. 8, 15622 doi:10.1038/ncomms15622 (2017).

Faculties

Sections

Events
30
July
2024
30.
07.
2024
01
August
2024
01.
08.
2024
08
August
2024
08.
08.
2024

Summer School in Social Sciences Methods

Faculty of Communication, Culture and Society
13
August
2024
13.
08.
2024

Cinema and Audiovisual Futures Conference 2024

Faculty of Communication, Culture and Society

The Future of Survival Public Event: AI and Generative humanity

Faculty of Communication, Culture and Society
14
August
2024
14.
08.
2024

The Future of Survival Public Event: Digital Migrations

Faculty of Communication, Culture and Society
15
August
2024
15.
08.
2024

The Future of Survival Public Event: "Listening to Ice"

Faculty of Communication, Culture and Society