USI has developed a strong network of relations with all other Swiss universities and with many foreign universities, establishing institutional relations and scientific collaborations. These privileged agreements provide the ideal framework for developing collaborations in terms of teaching, research and innovative projects.

USI has established strong institutional ties with a few leading universities in Lombardy, Italy – namely the Università Cattolica del Sacro Cuore (Milan), the Università degli Studi Milano-Bicocca, the University of Pavia and the University of Perugia. With these institutions, USI organises dual degree programs, Masters in communication sciences, economics, informatics and doctoral programs.

USI maintains a number of collaborations with institutions at the European level: such as Hanken School of Economics (Helsinki), Friedrich-Alexander Universität Erlangen-Nürnberg, Université Paris 1 - Panthéon Sorbonne, Università degli Studi di Napoli Federico II and at the extra-continental level, with the Virginia Polytechnic Institute and State University and the Communication University of China in the field of media.